Siddiqi et al., 2011; Yarwood et al., 2005) (Figure 1). These barriers tend to be even more pronounced, [...] midlife/older adults from multiple demographics. 3.1 Low-resistance IMST Until recently, IMST has been [...] the endothelium-derived vasoconstrictor, endothelin-1, were reduced in these patients (Campos et al., 2018)